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ea0077oc2.5 | Endocrine Cancer and Late Effects | SFEBES2021

A novel MiR-346-Directed DNA damage mechanism is regulated by its interaction with long non-coding RNA, NORAD, in prostate cancer

Fletcher Claire , Orafidiya Folake , Deng Lin , Yuan Wei , Lorentzen Marc , Cyran Oliwia , Varela-Carver Anabel , Constantin Theodora , Dobbs Felix , Figueiredo Ines , Gurel Bora , Parkes Eileen , Bogdan Denisa , Pereira Ronnie , Zhao Shuang (George) , Neeb Antje , Issa Fadi , Hester Joanna , Kudo Hiromi , Liu Yang , Philippou Yiannis , Bristow Robert , Knudsen Karen , Bryant Richard , Feng Felix , Reed Simon , Mills Ian , de Bono Johann , Bevan Charlotte

MiR-346 is an Androgen Receptor (AR)-activating miR that associates with DNA damage response (DDR)-linked transcripts in prostate cancer (PC). MiR-346 induces rapid and extensive DNA damage in PC cells through chromatin association, activation of transcription, R-loop formation and DNA replication stress, leading to checkpoint activation and cell cycle arrest. MiR-346 interacts with lncRNA, NORAD, in PC cells, which functions to maintain mitosis, DDR, and chromosomal integrity...

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Endocrine Abstracts

A novel MiR-346-Directed DNA damage mechanism is regulated by its interaction with long non-coding RNA, NORAD, in prostate cancer

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